This is a large neo-Renaissance building designed by the architect Enrico Presenti, and from here started the Linea Leopolda, the train for Pisa and Livorno. It was named after the Habsburg-Lorraine Grand Duke Leopold II.

The station, although only opened in 1847, was already transformed into a freight terminus in 1860, as passenger traffic had been moved to the Maria Antonia station which was more centrally located.
In recent years, this station which is a good example of railway architecture has become an exhibition center. At the moment, it is undergoing restoration work and will reopen as a museum.